EFFECTS OF M-NISOLDIPINE AND NISOLDIPINE ON THE HEMODYNAMICS AND REGIONAL BLOOD FLOW IN CONSCIOUS RABBITS
- VernacularTitle:间尼索地平与尼索地平对清醒兔血流动力学和局部血流量的影响
- Author:
Yujing GAO
;
Yunshan LI
;
Shaoxuan FU
- Publication Type:Journal Article
- Keywords:
m-nisoldipine;
Nisoldipine;
Hemodynamics;
Regional blood flow;
Radio-biomicrospheres;
Conscious rabbits
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
m-Nisoldipine ( m-Nis ) , isobutyl methyl 1 , 4-dihydro - 2, 6-dimethyl-4-( 3-nitrophenyl )-3 , 5-pyridine dicarboxylate, is a new calcium antagonist. Its effects on hemodynamics and regional blood flow as well as the distribution of cardiac output were evaluated in comparison with Nis with radio-biomicrospheres in conscious rabbits. ( 1 ) m-Nis ( 1 ?g/kg ? min-1 ? 10 min, iv ) increased cardiac output and cardiac index significantly (P0.05) ; ( 2 ) m-Nis increased stroke volume and left ventricular systolic work ( per beat ) while Nis slightly increased the former and decreased the later, and these differences were statistically significant (P
