Protective Effects of Silybin on Cultured Cardiomyocytes with Deprivation of Oxygen and Glucose
- VernacularTitle:水飞蓟宾对培养心肌细胞缺氧缺糖的保护作用
- Author:
Hong CHEN
- Publication Type:Journal Article
- Keywords:
silybin;
cardiomyocyte culture;
anoxic culture;
glucose deprivation;
isoproterenol
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
In this study, we used the anoxic cultured cardiomyocytes with the deprivation of glucose as a “ischemic” model. It was found that silybin could decrease the LDH release from ischemic cardiomyocytes, and act partly against the effect of isoproterenol on anoxic myocytes, i. e., reduce the cardiomyocyte injury by isoproterenol when used along with the isoprotercnol. The result shows that silybin may be a useful drug for the protection of ischemic cardiomyocytes.
