EFFECT OF PANAXATRIOL SAPONIN ( PTS ) ON HUMAN LYMPHOKINE PRODUCTION AND ITS CHARACTERISTICS
- VernacularTitle:人参三醇型皂甙促细胞因子诱生及其特点
- Author:
Zhigang TIAN
;
Guizhen YANG
- Publication Type:Journal Article
- Keywords:
Panaxatriol saponin;
Biological molecular synthesis;
Lymphokine Production
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Under stimulation of PHA,PHA + TPA,or PHA + PTS the time ke-netics of DNA,RNA,protein synthesis and lymphokine secretion by human lymph node cell expressed different responses. The PTS did not increase the DNA and RNA synthesis, but increased the protein synthesis ( 60% ) . TPA increased the RNA synthesis ( 18% ) , therefor increased the protein synthesis ( 40% ) . Both of TPA and PTS increased the production of 5 kinds of lymphokines (IL-1 , IL-2 , IL-3, BCGF, TFNr). We infer that PTS and TPA increase the lymphokine production through different gene regulation. TPA Promotes the translation of lymphokine mRNA。
