EFFECTS OF VERAPAMIL ON DNA, RNA AND PROTEIN SYNTHESIS OF HUMAN FIBROBLASTS
- VernacularTitle:维拉帕米对人成纤维细胞DNA、RNA和蛋白质合成的影响
- Author:
Naifeng LIU
;
Yuanwei HUANG
;
Dingan LOU
- Publication Type:Journal Article
- Keywords:
Calcium antagonists;
Verapamil;
Nucleic acid;
Protein, 〔~3H〕 Thymidine;
〔~3H〕 Uridine;
〔~3H〕 Leucine
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the action of calcium antagonists on metabolism of intracellular macromolecules, The authors observed the effects of verapamil on the incor-poration of 〔 3H 〕 TdR, 〔 3H 〕 UR and 〔 3H 〕 Leu into human fibroblasts. The inhibitory effects on DNA and RNA synthesis were concentration dependent, ID50 was l2.3mg/L and 22mg/L, respectively. The inhibitory effect on the synthesis of protein was weak.
