STRUCTURAL PROPERTIES OF THE LIPID A COMPONENT OF THE LIPOPOLYSACCHARIDE (ENDOTOXIN) ISOLATED FROM BACTERIODES FRAGILIS NCTC 9343
- VernacularTitle:脆弱类杆菌NCTC9343内毒素类脂A的结构特征
- Author:
Binghua JIAO
;
Al CT
- Publication Type:Journal Article
- Keywords:
B. fragilis;
lipopolysaccharide (endotoxin);
lipid A;
gas-liquid chromatography;
structural properties
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Various chemical and gas-liquid chromatographic analyses indicate that the lipid A backbone of the lipopolysaccharide (LPS) isolated from Bacteriodes fragilis NCTC 9343 is chemically constituted by a ?1, 6-interlinked D-gluco-samine disaccharide. It is phosphorylated at its 1-position by a glycosidic-linkage while the ester-bound phosphate present generally in other lipid A is depleted. The lipid A is lower fatty acylated in the amount of 5.2 fatty acids per lipid A molecule (of which 0.73 forms 3-acyloxyacyl groups). The LPS containing such a lipid A component has been shown endowing with a weaker endotoxicity.
