ULTRASTRUCTURAL CHANGES OF SKELETAL MUSCLE OF HINDLIMBS IN RATS DURING ISCHEMIA-REPERFUSION INJURY
- VernacularTitle:大鼠肢体缺血再灌流损伤骨胳肌超微结构的变化
- Author:
Qin HUANG
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion injury;
skeletal muscle;
ultrastructure
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
In this study, the ultrastructural changes of skeletal muscle of hindlimbs in rats were observed. Skeletal muscle of 5 h ischemia showed diminished glycogen granules, swelling of mitochondria, clearing of mitochondrial matrix, breakage of mitochondrial crista and dilatation of sarcoplasmic reticulum. Skeletal muscle of 5 h ischemia and 1/2 h or 12 h reperfusion showed high amplitude swelling of mitochondria with rupture of mitochondrial membrane, dense granules in mitochondrial matrix and complete loss of normal organization of myofibrils. The results demonstrate that reperfusion after prolonged ischemia exaggerates tissue injury.
