Effects of Soman on Lymphocyte Proliferation in Mice
- VernacularTitle:梭曼对小鼠淋巴细胞增殖能力的影响
- Author:
Zhaojun DONG
;
Tingzhi WANG
- Publication Type:Journal Article
- Keywords:
Soaman/PD;
Lympbocytosis/DT;
Cholinesterase
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of soman on lymphocyte proliferation are investigated in mice. 1 d after soman(154 ?g/kg,sc) poisoning B-lymphocyte reaction to lipopolysaccharide(LPS) is inhibited significantly and is persistent.T-cell proliferation response stimulated by concanavalin(Con A)has a 2-phase changeson the 1st day an increase followed by a dramatical reduction. Both the decreases of T-and B-lymphocyte mitogenic response and the primary increase of T-cell response show a close correlation with the doses of soman in this experiment. It has no relation to the change of the whole blood cholinesterase activity.
