METHOD FOR MEASURING IL-1 AND EFFECTS OF TOTAL GLUCOSIDES OF PAEONY ( TGP ) ON IL-1 PRODUCTION
- VernacularTitle:白细胞介素Ⅰ的检测及白芍总甙对其产生的影响
- Author:
Junshan LIANG
;
Wei WEI
;
Aiwu ZHOU
- Publication Type:Journal Article
- Keywords:
Interlereukin l;
Macrophage;
Total glucosides of paeony
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Method for measuring interleukin 1 ( IL -1 ) and effects of total glucosides of paeony(TGP) on IL -1 production were studied. The results showed that the best concentration for LPS -induced IL-1 production of M s in rats was 8mg/L, the best dilution for IL-1 of LPS-induced M s production was 1 : 90. TGP ( 0 .5 - 12 .5mg/L ) enhanced LPS-induced IL -1 production in a concentration dependent manner, but diminished in the higher concentration of TGP ( 62 .5~l25mg/L ) , the concentration-effect curve seems to be bell-shaped. The data suggested that TGP had two-sided regulatory effects on LPS -induced IL production of M s in rats.
