THE EFFECT OF NICARDIPINE ON CARDIAC TOXICITY INDUCED BY OUABAIN
- VernacularTitle:尼卡的平对哇巴因心脏毒性作用的影响
- Author:
Jianxin ZHANG
;
Wenping ZHU
;
Shuxun WU
- Publication Type:Journal Article
- Keywords:
Ouabain;
Cardiac toxicity;
Nicardipine
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of our study is to determine whether the slow Ca2 + channel blocker, nicardipiae, could prevent or reduce the cardiac to-xicity induced by ouabain. The guinea pig heart in vivo and vitro perfusion of the isolated heart were used for the study . The results demonstrated that nicardipine ( i .v .50?g? kg-1') could significantly increase the doses of ouabain induced arrhythmias and death(P
