PROTECTIVE EFFECTS OF JATRORRHIZINE ON MYOCARDIAL ISCHAEMIA AND REPERFUSION DAMAGE IN EXPERIMENTAL ANIMALS
- VernacularTitle:药根碱对实验动物心肌缺血和复灌性损伤的保护作用
- Author:
Chao CHEN
;
Hong HAN
;
Dachao FANG
- Publication Type:Journal Article
- Keywords:
Jatrorrhizine;
Myocardial ischaemia;
Reperfusion;
Arrhythmias
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Jat(lOmg/kg iv) administered 5 min prior to ligation of left anterior descending coronary artery significantly decreased the incidence of arrhy-thmias(VT and VF)and mortality of rats during ischaemia and reper-fusion.It also delayed the onset and shortened the duration of arrhythmias. The size of myocardial infarction caused by coronary artery ligation was decreased by Jat ( 0.75mg/kg iv. 1 h before and 6 h after operation) in rabbits.
