CHANGES OF LIVER MICROSOMAL DRUG-METABOLIZING SYSTEM AND LIPOPEROXIDATION ACTIVITY IN SCALDED RATS AND THE EFFECTS OF SILYBIN
- VernacularTitle:烫伤后大鼠肝脏药物代谢酶和脂质过氧化活性的变化以及水飞蓟宾的作用
- Author:
Jiner XIE
- Publication Type:Journal Article
- Keywords:
liver rnicrosorne;
drug metabolizing system;
lipoperoxidation;
scalding;
rats
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The dynamic changes of liver microsomal drug-metabolizing system ( MDMS) and lipoperoxidation were studied in scalded rats.The effects of treatment with vitamin E and silybin were also evaluated.The results showed that liver microsomal cytochrome P-450 content, and p-nitroanisole demethylase (p-NOD) and aniline hydroxylase (AH) activity decreased markedly postburn.On the contrary, liver lipoperoxide and microsomal lipoperoxidation increased significantly after scalding.Both the increase of liver lipoperoxide and microsomal lipoperoxidation and the decrease of MDMS activity were prevented by vitamin E and silybin treatments.
