EFFECTS OF SYSTEMIC POISONING BY SULPHUR MUSTARD ON CELL DNA BIOSYNTHESIS OF INTERNAL ORGANS AND PROTECTIVE ACTION OF ANTIDOTES IN MICE
- VernacularTitle:芥子气全身中毒对小鼠脏器细胞DNA生物合成的影响及抗毒剂的防护作用
- Author:
Jiejun SONG
- Publication Type:Journal Article
- Keywords:
sulphur mustard (SM);
DNA;
[3H]-TdR;
antidote;
sodium thiosulphate;
unithiol (DMPS)
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we observed the efTects of systemic poisoning by sulphur mustard (SM) on DNA biosynthesis of internal organs and protective action of antidotes in mice.The results showed that the systemic poisoning by SM produced a strong depression of [3H]-TdR incorporation into DNA biosynthesis, which was characterized by rapidity, severity and rapid recovery.It is suggested that mammal an organism has a marked physiological compensation, regeneration and repair activity for DNA damage.Antidote sodium thiosufate alone or in combination with unithiol (DMPS) has satisfactory protective effects on depression of DNA biosynthesis in mice poisoned by SM.
