A Morphometric Study of the Lungs in Blast Injured Rats
- VernacularTitle:冲击伤大鼠肺形态变化的定量研究
- Author:
Min ZHAO
- Publication Type:Journal Article
- Keywords:
blast injury/CO;
lungs/PA;
morphometry/MT;
pulmonary diffusion capacity
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The morphological changes of the rat lung with blast injury are quantitified with a stereological method. After blast the pulmonary capillary volume and internal surface area decreased significantly, arithrnatic and harmonic mean thickness of the air-blood barrier, the volumes of P'MN and platelet in capillury increased remarkably. The morphometric lung diffusion capacity of oxygen (DLO2) is reduced markedly mainly due to the decrease of diffusion capacity of air-blood barrier and erythrocyte. The change of DLO2 is closely correlated with the arterial blood oxygen pressure, indicated that the damage of pulmonary capillary is one of the main causes of alveolar bleeding and the early respiratory insufficiency. A mathematic relation can be established between the intensity of the blast wave and the corresponding morphological changes of the injured lungs.
