POTENTIATING EFFECT OF ISOPRINOSINE ON IMMUNE RESPONSES IN MICE
- VernacularTitle:异丙肌苷对小鼠免疫功能的增强作用
- Author:
Zhibin LIN
;
Li MA
;
Dong XIA
- Publication Type:Journal Article
- Keywords:
Isoprinosine;
Cyclophosphamide;
Hemolysin;
Plaque forming cell ( PFC );
Delayed cutaneous hepersensitivity ( DCH );
Lymphocyte proliferation;
Aged immunodeficiency
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Isopinosine (ISO, 25?100 mg/kg?d-1ip for 4 or 5d) significantly increased the production of serum hemolysin-and spleen plaque forming cell ( PFC) in normal mice immunized with SRBC. The same result was observed in immunosuppressive mice induced by cy clophospha-mide. In 16 month aged mice, ISO (ip for 5 d) showed potentiating effect on anti-SRBC PFC response at the dose of 2 .5 mg/kg, no significant effect at the dose of 5 .0 mg/kg, and inhibiting effect at the dose of 25 and 100 mg/kg respectively. 1SO(25,50 and 100 mg/kg?d-1 ip for 9 or 10 d ) remarkably enhanced delayed cutaneous hypersensiti-vity (DCH) to 2, 4 -dinitrochlorobenzene (DNCB) in normal mice as well as in immunosuppressive mice induced by cyclophospha-mide. ISO (5, 10 and 20 mg/L ) signficantly increased ConA-induced lymphocyte proliferation of spleen cells from C57BL/6J mice in vitro. There was also potentiating effect on lymphocyte proliferation induced by ConA in 16 month aged mice.
