EFFECTS OF NEFERINE ON RAT ECG & THE SURFACE POTENTIAL OF TOAD SCIATIC NERVE
- VernacularTitle:甲基莲心碱对大鼠心电图和蟾蜍坐骨神经动作电位的影响
- Author:
Guirong LI
;
Jiaqing QIAN
;
Fuhua LU
- Publication Type:Journal Article
- Keywords:
Neferine;
Quinidine;
Tetrandrine;
ECG in rat
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Neferine, an alkaloid, isolated form Nelumbo nucifera Gaertn,has antiarrhytbmic effect. The present report deals with its action on the ECG in rat & the surface potential of toad sciatic nerve.Neferine could prolong ECG, P-R & Q-T intervals, and widen QRS in a dose-dependent manner, The effects are similar to quini-dine, and dissimilar to tetrandrine. The inhibitory effects of neferine & quinidine on the surface potential of toad sciatic nerve are similar in potency.
