EFFECTS OF TOTAL FLAVONES OF HIPPOPHAE RHAM-NOIDES L (TFH) ON IMMUNOLOGICAL FUNCTION IN MICE
- VernacularTitle:沙棘总黄酮对小鼠免疫功能的影响
- Author:
Fei ZHONG
;
Yun JIANG
;
Fenfen WU
- Publication Type:Journal Article
- Keywords:
Total Flavones of Hippophae Rhamnoides L. (TFH);
Lymphocyte proliferation;
Lysozyme;
Hemolysin;
Agglutinin;
SRFC
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
TFH was isolated from the fruits of Hippophae Rhamnoides L. A study was made cf the effects of TFH on the immune reaction in animals. TFH ( 5.0mg/kg? d-1 sc?6d)remarkably enhanced the pha-gocytic activity of peritoneal exudate macrophages. The content of lysozyme in mice ( TFH 2mg/kg?d-1 ip?7d) & serum complement in guinea pig also were remarkably elevated. TFH caused significant increases of quantitative hemolysin of SRBC ( QHS ) in normal mice. At the dose of 2mg/kg?d-1 ip?8d TFH increased the production of hemolysin serum and agglutinin in normal mice as well as in immunodepressed mice induced by cyclophosphamids. TFH ( 6.25-50mg/L) markedly enhanced Con A-induced lymphocyte proliferation of mouse spleen cells in vitro. These results suggested that TFH had certain immunopotentiation in animals.
