STUDY ON THE MECHANISM OF RELAXATION OF BERBAMINE ON THE ISOLATED RABBIT RENAL ARTERIES
- VernacularTitle:盐酸小檗胺松弛离体兔肾动脉条作用原理的研究
- Author:
Shangkui SUN
;
Yunrui GAO
;
Wenhan LI
- Publication Type:Journal Article
- Keywords:
Berbamine;
Verapamil;
Calcium antagonist;
Antago-nistic parameter;
Renal arteries.
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The contraction of the isolated rabbit renal arteries induced by noradrenaline, high K+ & calcium could be relaxed by berbamine ( BA ). BA shifted dose-response curve of noradrenaline, high K+ snd calcium to the right, but the maximal response was reduced. The antagonistic parameter pD' 2 of berbamine on calcium contrac-tion was 4.76, which is similar to the verapamil (pD'2=5.68). Therefore berbamine can be considered as a non-competitive calcium antagonist.
