Ubiquitin Ligases in Cholesterol Metabolism.
10.4093/dmj.2014.38.3.171
- Author:
Wei JIANG
1
;
Bao Liang SONG
Author Information
1. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. blsong@sibcb.ac.cn
- Publication Type:Review
- Keywords:
Cholesterol metabolism;
Protein homeostasis;
Ubiquitin ligases
- MeSH:
Cholesterol*;
Drug Discovery;
Homeostasis;
Ligases*;
Metabolism*;
Protein Stability;
Receptors, LDL;
Ubiquitin*
- From:Diabetes & Metabolism Journal
2014;38(3):171-180
- CountryRepublic of Korea
- Language:English
-
Abstract:
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed.
