The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity.
10.4093/dmj.2014.38.3.181
- Author:
In Kyu LEE
1
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. leei@knu.ac.kr
- Publication Type:Review
- Keywords:
Diabetes mellitus;
Obesity;
Pyruvate dehydrogenase (acetyl-transferring) kinase
- MeSH:
Acetyl Coenzyme A;
Adenosine Triphosphate;
Amino Acids;
Carbon Dioxide;
Coenzyme A;
Diabetes Mellitus;
Fatty Acids;
Glucose;
Glycerol;
NAD;
Obesity*;
Oxidoreductases*;
Phosphotransferases*;
Pyruvate Dehydrogenase (Lipoamide)-Phosphatase;
Pyruvate Dehydrogenase Complex;
Pyruvic Acid*
- From:Diabetes & Metabolism Journal
2014;38(3):181-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.
