THE CYTOTOXICITY TO AUTOLOGOUS TUMOR CELLS OF TUMOR-INFILTRATING LYMPHOCYTE (TIL) ACTIVATED BY IL-2 AND ITS COMPARISON WITH THE CYTOTOXICITY OF LAK CELLS
- VernacularTitle:IL-2激活的TIL对自体肿瘤细胞的杀伤活性及其与LAK细胞活性的比较
- Author:
Xuetao CAO
- Publication Type:Journal Article
- Keywords:
tumor-infiltrating lymph.ocyte;
interleukin-2;
lymphokine-activated killer cells,cytotoxicity;
adoptive immunotherapy
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
We have shown that tumor-infiltrating lymphocyte (TIL) cultured in interleukin-2 (IL-2) acquired a potent antitumor activity and had target cell specificity.TIL exhibited higher cytotoxicity to autologous tumor cells than that of LAK cells grown under identical conditions (P0.05), so that it is possible to treat recurrent and unresectable tumor using TIL periodically.
