EXPERIMENTAL STUDY ON CHANGES OF CELLULAR IMMUNITY AFTER FRACTURE
- VernacularTitle:骨折后细胞免疫功能降低的实验研究
- Author:
Qingbin SUN
- Publication Type:Journal Article
- Keywords:
fracture;
cellular immunity;
disease models,animal
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the changes of cellular immunity and relationship between cellular immunosuppression and infection after fracture, we, examined delayed hypersensitivity response, lymphocyte transformation and leucocyte migration inhibition index in 25 dogs.It was found that delayed hypersensitivity response to DNCB,, lymphocyte transformation to phytohemagglutinin and leucocyte migration inhibition index were significant- ly decreased l to 7 d after fracture in comparison with the control before fracture.The function of cellular immunity was restored two weeks later in the uninfected dogs, but it was not restored in dogs with osteomyelitis even 30 d after fracture.The results suggest that traumatic fracture can impair host cellular immunity.Continual cellular immunosuppression renders the host more susceptible for bacteria and results in infectious complications.Cellular immune indices can be used as valuable ones to pievent and reat infectious complications post-fracture.
