CLINICAL AND MORPHOLOGICAL INVESTIGATIONS OF CALCiTONINOMA
- VernacularTitle:降钙素瘤的临床及形态学观察(附二例报告)
- Author:
Jianping ZHONG
- Publication Type:Journal Article
- Keywords:
calcitoninoma;
APUDoma;
C cells;
electron microscopy;
immuno-histochemistry
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Two rare cases of calcitoninoma (C cell AP0Doma)were diagnosed by electronmi-croscopic and immunohistochemical evidence though the histopathological findings had failed to sstablish.Bath cases rac^ivad operative tr^atinsnt and recovery was uneventful.The diagnosis is consistent with the follow-up observation so far.Patient A had retroperitoneal and hepatic multiple calcitoninoma and patient B suffered from ectopic thyroid medullar carcinoma.Well differentiated calcitoninoma cells contained special APUD granules which were spherical, membrane bound and measured 300-700nm in diameter.The characteristic APUDamyloid was found in neoplastic cells of palient A, but not in all cells.Patient B had three types of endocrine cells, though the tumor was mainly made up of C cells.Calcitonin-producing C cells were present clearly in two cases with double PAP method.Diagnosis, clinical treatment and the origin of calcitoninoma are discussed.The authors emphasize that electron microscopic and immunohistochemical examinations are important in the diagnosis of APUDoma, and good results might be obtained by early operative treatment.
