THE INFLUENCE OF JIAOGULAN EXTRACT ON PLATELET AGGREGATION AND ARACHIDONATE METABOLISM IN RABBITS
- VernacularTitle:绞股蓝提取物对家兔血小板聚集和花生四烯酸代谢的影响
- Author:
Lin LI
;
Youyu JIN
- Publication Type:Journal Article
- Keywords:
Gynostemma pentaphyllum;
Platelet aggregation;
Thromboxane;
Prostacyclin;
6-keto-prostaglandin FI?;
Enzvme immunoassav
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
jiaogulan ( Gynostemma pentaphyllum) extract (0.25~2g/L. final concentration) obviously inhibited the platelet aggregation & TXB2 release induced by arachidonic acid ( AA ) in vitro, and the ID50 of inhibiting TXB2 release was 0.28g/L. With the dose of 35mg/kg i. v. , it evidently inhibited platelet aggregation at 10 & 20 min after injection, and also markedly decreased TXB2 released by platelets during 10~40 min after injection, especialy within 20 min. Jiaogulan extract (0.25~4g/L) did not influence 6-keto-PGF1? release of aorta thoracalis of rabbits in vitro. Enzyme immunoassay was used to measure the content of TXB2 & 6-keto-PGF1? in the experiments. The above results suggest that Jiaogulan extract may decrease TXA2/PGI2 ratio.
