EFFECTS OF TETRANDRINE ON THE HEART CONDUCTION SYSTEM IN ANESTHETIZED RABBITS
- VernacularTitle:粉防己碱对麻醉兔心内传导系统的影响
- Author:
Guirong LI
;
Dachao FANG
;
Fuhua LU
- Publication Type:Journal Article
- Keywords:
Tetrandrine;
Quinidine;
Heart conduction system
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Tetrandrine, a bis-benzy 1-i soqui noline alkaloid isolated from Radix Stephania tetrandra S. Moor, was proved to be a calcium antagonist. Its effects upon the heart conduction system were investigated in anesthetized rabbits.Tetrandrine 8 mg/kg iv could prolong the sino-atrial conduction time & the sinus node recovery time from 50 ? 13 ms & 286? 36 ms to 75?19 ms ( n= 8 , P
