EFFECT OF ADRIAMYCIN ON HEART PEROXIDATION IN MICE
- VernacularTitle:阿霉素对小鼠心肌过氧化代谢的影响
- Author:
Xin CHENG
;
Guanglu XU
- Publication Type:Journal Article
- Keywords:
Adriamycin;
Mice;
Heart;
Petoxidation
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In mice, adriamycin (l7.5mg/kg, ip ) produced heart peroxida-tion abnormality including increased TBA value & decreased gluta-thione peroxidase activity, respectively. But the change of former was not parallel to the latter. The drug also produced early pathological change of the heart i.e. more D-PAS positiveness. The results suggested that the early heart pathological change produced by adriamycin may be related to increased accumulation of pero-xi dative products.
