THE EFFECTS OF CIMETIDINE & RANITIDINE ON PENTO-BARBITAL SLEEPING TIMES IN RATS & MICE
- VernacularTitle:西咪替丁对戊巴比妥睡眠时间的影响
- Author:
Guocun WANG
;
Mingwei QIAN
;
Cheng CAI
- Publication Type:Journal Article
- Keywords:
Ranitiidine;
Cimetidine;
Pentobarbital;
Sleeping time;
Blood concentration
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The pentobarbital sleeping times ( PST ) in rats and mice pretreated with ranitidine acutely or chronically do not differ significantly from the control groups. But the PST pretreated with cimetidine acutely and chronically both do prolong significantly in rats and mice. The blood pentobarbital concentration in the male rats pretreated with cimetidine chronically is significantly higher than the ranitidine and control groups. Close relationship between the PST and the blood pentobarbital concentration has been observed.
