EFFECTS OF GINSENOSIDES ON THE ACTIVITIES OF Ca~(2+)-ATPase & Mg~(2+)-ATPase IN RABBIT CEREBRUM IN VITRO
- VernacularTitle:人参茎叶皂甙在体外对兔脑Ca~(2+)-ATP酶和Mg~(2+)-ATP酶活力的影响
- Author:
Gang HU
;
Ruiyi ZONG
- Publication Type:Journal Article
- Keywords:
Ginsenosides;
Chlorpromazine;
Rabbit cerebrum;
Ca 2+-ATPase;
Mg2+-ATPase
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of saponins extracted from stems & leaves of Panax ginseng C.A.Meyer including the total ginsenoside ( GNS) , panaxad-iol saponin ( PDS ) & panaxatriol saponin ( PTS ) on the activities of Ca2+-ATPase & Mg2+-ATPase in rabbit cerebral microsomes were studied in vitro. It was found that GNS & PTS significantly inhibited the activities of Ca2+-ATPase & Mg2+-ATPase. The activity of Ca2+-ATPase was activated by PDS at the concentrations of 10 & 100mg/L, and it dramatically inhibited the activity of Ca2+-ATPase the concentration of 1000mg/L. Furthermore, the activity of Mg2+-ATPase was inhibited by PDS at the concentrations of 100 & 1000mg/L. Chlorpromazine ( 0 .35 & 0 .70 mmol/L ) possessed the inhibitory effects on the activities of both Ca2+-ATPase & Mg2+-ATPase.
