STUDY ON PHARMACOKINETICS OF TMPH FOR INTRAVENOUS INJECTION IN RAT
- VernacularTitle:盐酸川芎嗪静脉注射的药物动力学研究
- Author:
Zhili HUANG
;
Chen ZHOU
;
Biying WU
;
Ruiyuan SUN
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine Hydrochloride;
Pharmacokin-eties Compartment model;
Marquardt method
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Pharmacokinetics of Tetramethylpyrazine Hydrochloride (TMPH) in rat was studied by using Ultraviolet Spectrophotometry. After a bolus iv injection of TMPH 30 mg/kg to rat, the pharmacokinetic characteristics are found to fit a two-compartment open model. The Pharmacokinetic parameters are: t 1/2? = 0 .1441h, t 1/2? = l .6953h, K21=2.1850h-1, K10=0.8605h-1, K12= 2 .0723h-1, AUC = 83 .3660mg?L -1h, CL = 0.3599L?kg-1h-1, Yc =0 .4182L?kg-1 , Vss =0 .7975L.kg-1
