EFFECTS OF RHYNCHOPHYLLlNE ON CONTRACTILITY OF ISOLATED GUINEA-PIG TAENIA COLI
- VernacularTitle:钩藤碱对豚鼠结肠带收缩反应的影响
- Author:
Ansheng SUN
;
Qin WU
;
Guoxiong LIU
- Publication Type:Journal Article
- Keywords:
Rhy nchophylline;
Verapamil;
Acetylcholine;
Guineapig taenia coli
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The contractions induced by acetylcholine or Ca2 + after high-K+ depolarization in isolated guinea-pig taenia coli were markedly inhibited by rhynchophylline (Rhy). It caused rightward displacement of the dose-response curve for CaCl2 & significantly depressed the maximal response, showing a non-competitive antigonism. The pD'2 value of Rhy was 4.95?0.05. In Ca2+-free solution,Rhy similar to verapamil (Ver), inhibited acetylcholine-induced contraction of guinea-pig taenia coli, which is dependent on Ca2+ released from an intracellular store. After Ca2+ concentration in bath solution was restored, Ver did not influence the contraction of taenia coli depending on extracellular Ca2 + , However 40 ?mol/L Rhy could exhibit marked inhibitory action.
