AN EXPERIMENTAL STUDY OF CRANIOCEREBRAL INJURY CAUSED BY 7.62 mm BULLETS IN DOGS Ⅱ.THERAPEUTIC EFFECT OF HIGH DOSE DEXAMETHASONE
- VernacularTitle:7.62 mm弹颅脑火器伤实验研究——Ⅱ.大剂量地塞米松防治继发病理损害的作用
- Author:
Cheng ZHU
- Publication Type:Journal Article
- Keywords:
head injury;
gunshot wound;
experimental model;
dexamethasone pathology of brain;
brain blood barrier
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of high dos; dexamethasone(5mg/kg wt, intravenous injection)to prevent and treat the secondary pathological damage of craniocerebral injury was studied in animal models of craniocerebral injury caused by high-velocity missiles in dogs.We observed ths physiological changes, analyzed the value of serum and. cerebrospinal fluid lactate dehydrogenase, estimated the permeability of blood brain barrier (BBB) and studied brain pathology by light and electron microscopy.The results suggest high dose dexamethasone can help to restore ths structure and function of BBB, protect brain cells as well as lessai the secondary pathological damage in tha respiratory and circulatory systems and reduce th production of lipoptrox-ides(LPO).
