A STEREOLOGIC ANALYSIS OF LAMELLAR BODY WITHIN PULMONARY ALVEOLAR TYPE Ⅱ CELLS IN DOGS WITH ACUTE HEMORRHAGIC PANCREATITIS
- VernacularTitle:犬急性出血性胰腺炎时Ⅱ型肺泡上皮细胞板层体体视学的研究
- Author:
Jianjun WANG
- Publication Type:Journal Article
- Keywords:
acute hemorrhagic pancreatitis;
alveolar type II cells;
lamellar body;
stercology;
choloroquine;
disease model,animal
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A stereologic study of lamellar bodies within pulmonary alveolar type II cells in dogs with experimental acute hemorrhagic pancreatitis(group P)and in dogs inje- cted muscularly with choloroquine before inducing pancreatitis (group PI)was carried out.Our findings showed that volumerical density (Vv), surface density (Sv)and numerical density(Nv)of lamellar bodies were decreased by 29.06%,30.28% and 40.75% in the group P as compared with those in the control group (group N), respectively, and their Sv and Nv were decreased by 23.8% and 30.26% in comparison with those in the group PI.The results suggest that the lung injury resulting from acute hemorrhagic pancreatitis was characterized by alveolar surfactant System damage.Dramatical decrease in the number of the lamellar bodies affected the surface tension of alveoli in a certain degree, leading to atelectasis.There was a relationship between lung injury and the effect of PLA2(phospholipidase A2).Choloroquine might play a role in maintaining the number of lamellar bodies.
