The Regulatory Effects of Dexamethasone on the Acute Experimental Serum Sickness in Rabbits
- VernacularTitle:地塞米松对家兔急性实验性血清病的调节作用
- Author:
Shunyou WANG
;
Xihua ZHU
- Publication Type:Journal Article
- Keywords:
Dexamethasone/PD;
Serum sickuess/DT;
Antigen-antibody complex;
Superoxide dismutase
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
This experiment takes the apute experimental serum sickness (AESS) in rabbits as an animal model to investigate the mechanism of the regulatory effects of Dexamethasone (DX) . The results show. DX doesn't inhibit the production of anti-BSA antibody but induces the tendency to increase the level of antibody in rabbits with DX administration on early days (EL, EH); immune complexes(BSA - anti-BSA IGg, CIC) in the rabbits of EL and EH are significantly increased comparing with the later days (LE, LH) and positive controls. Non-specific esterase stainings and the pathological changes of kidney sections are markedly lessened though the amount of anti - BSA antibody, circulating immune complex (CIC) and superoxides dismutase activity in the rabbits of LE and L H are the same as the positive control. The outcome of protecting kidneys of AESS rabbits from injury by DX administration . probadly results from the effects of that DX inhibits infiltration of monocytes into the glomeruli. The role of oxygen radicals in AESS needs further investigation.
