ONE EXPERIMENTAL STUDY OF PREVENTIVE EFFECT OF CHINA-MADE ISOCRYSTAL PIRENZEPINE ON RESERPINE-IN-DUCED ULCER
- VernacularTitle:国产异晶形哌吡氮平预防和血平性溃疡的实验研究
- Author:
Keyi XU
;
Jianquan TAN
;
Cunkun FAN
- Publication Type:Journal Article
- Keywords:
China-made isocrystal pirenzepine;
China-made pirenze-pine;
Rats;
Reserpine;
Gastric ulcer
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Effect of China-made isocrystal pirenzepine ( IPRZ ) on experimental ulcer produced by reserpine in rats was studied & the antiulcer effect of China-made IPRZ was compared with that of China-made PRZ. Our results showed that China-made IPRZ given by either sc ( 25-100 mg/kg ) or ig ( 25-100 mg/kg ) exerted a marked antiulcer effect on reserpine-induced gastric ulcer in rats.The antiulcer effect was increased with the increase of dose of China-made IPRZ. When China-made IPRZ was given by sc, its antiulcer effect was as potent as China-made PRZ, but when it was given by ig, its antiulcer effect was lower than China-made PRZ .This result suggest that the bioavailabili-ty of China-made IPRZ given by ig was lower than China-made PRZ.
