CLINICAL SIGNIFICANCE OF PLASMA FIBRONECTIN DETERMINATION IN THE PATIENTS WITH CHRONIC COR PULMONALE
- VernacularTitle:血浆纤维粘连蛋白测定对判断肺源性心脏病预后的意义
- Author:
Yanyan LIU
- Publication Type:Journal Article
- Keywords:
Cor pulmonale,fibronectin
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Plasma fibronectin(FN) level was measured by single radial immunod if fusion method in 58 patients with chronic Cor pulmonale during acute, remission and deterioration stages, 20 cases of chronic bronchitis, 10 cases of rheumatic heart disease, and 60 healthy people as controls.We analysed the relationship between the changes of plasma FN level and the degree of the respiratory failure, pulmonary infection and acid-base disturbance in experimental groups.The results showed that plasma FN levels of the controls, and the patients with chronic bronchitis and rheumatic heart disease were 322.4?60mg/L,263?40mg/L and 333.51 48mg/L, respectively.Plasma FN level was significantly decreased in patients with Cor pulmonale during acute stage(l46?67mg/L), gradually restored at remission stage (286?62mg/L) and markedly decreased in deterioration stage (101?39mg/L).It was ako markedly decreased in the patients with severe respiratory failure, pulmonary infection and acid-base disturbance.The authors suggest thai: placma FN may be used as a valuaole parameter to evaluate the clinical severity and prognosis of the patients with Cor pulmonale.The decrease of plasma FN level in patients with chronic Cor pulmonale may be due to its increased consumption and decreased synthesis in acute and deterioration stages.
