INFLUENCE OF LYCOBETAINE ON THE CELL CYCLE & MITOSIS IN MOUSE EHRLICH CARCINOMA CELLS
- VernacularTitle:石蒜碱内铵盐对小鼠艾氏腹水癌细胞周期及核分裂的影响
- Author:
Peiqing ZHOU
;
Bin XU
- Publication Type:Journal Article
- Keywords:
Lycobetaine;
Mitosis;
Cell cycle
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Lycobetaine ( AT-1840 ) is an effective antitumor substance. In the present work it was demonstrated that in a dose of 40 pig/kg AT-1840 could decrease the percentage of G, cells, meanwhile it increased G2 + M cells remarkably by means of flow fluocytometry method, AT-1840 could also inhibit the progression of cells from G2 to G1 phase. 8 to 72 h after, the injection the mitotic index was decreased significantly and recovered gradually in 6 d. It could inhibit the prophase and metaphase greatly, but had no marked influence on anaphase & telophase.
