EFFECTS OF ZnSO_4 ON EXPERIMENTAL ARRHYTHMIAS
- VernacularTitle:硫酸锌对实验性心律失常的影响
- Author:
Xin MA
;
Xiaoguang LI
- Publication Type:Journal Article
- Keywords:
ZnSO_4;
Arrhythmias;
Antiarrhythmia;
Aconitine;
Chloroform
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The antiarrhythmic actions of ZnSO4 (Zinc) were studied in ex-perimental arrhythmias models. ZnSO4 10mg/kg(iv) significantly coun-teracted the arrhythmias, induced by aconitine or BaCl2 rats.It was shown to shorten the duration of arrhythmias induced by chloroform-epinephrine in rabbits. In mice, ZnSO4 20 ?g/10g(ip) decreased the incidence of ventricular fibrillationbychloroform. However, ZnSO4 did not decrease the incidence of CaCl2-induced , venticular fibrillation, the threshold and lethal doseofouabain in producing ventricular permature beats, ventricular fibrillation in guinea pigs.
