A STUDY OF STRUCTURE-EFFECT RELATIONSHIP OF CLOFIBRATE AND ITS HOMOLOGUE
- VernacularTitle:安妥明及其同系物构效关系研究
- Author:
Tijuan CHENG
- Publication Type:Journal Article
- Keywords:
Clofibrate;
Ethyl-p-acetaminophenoxy-acetate;
Ethyl-p-chlorophenoxy-acetate;
Structure-effect relationship
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of decreasing serum cholesterol & structure-effect relation ships of clofibrate & its homologue were studied in this paper . The model of high lipid animal was made by ip yolk emulsion. Effects of 3 drugs for serum cholesterol were observed . These results showed that clofibrate (200mg/kg) & ethyl-p-acetaminophenoxy-ac etate (200,100mg/kg) both lowered serum cholesterol levels (P
