SYNTHESIS AND TUMOR-PHOTOBIOLOGICAL ACTIVITIES OF MESO-TETRASUBSTITUTED PHENYL PORPHINES
- VernacularTitle:中介-四(取代苯基)-卟吩衍生物的合成及肿瘤光生物活性
- Author:
Shaoyin WANG
- Publication Type:Journal Article
- Keywords:
tumor photochemodiagnosis and photochemotherapy;
porphines
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The preparation of 7 meso-tetrasubstituted phenyl porphines and the photosensitizing effects and tumor-photobiological activities of 4 of these compounds in cell-free system are presented here.It has been shown by the data in determination of the ability of compounds Ⅰ1_4 to sensitize photooxidation of NADPH in D2O under the illumination _of He-Ne laser that the ability to generate active oxygen species of them was much higher than those of YHpD and PsD-007.But they were weak in photoinactivation for the cultured human tongue squamocell cancer cells TCA-8113 in vitro.However, they were effective, in some degree, in the photo-localization and photodynamic therapy of sarcoma Si80 in mice.Severe delayed phototoxic reaction occurred in the mice administered these compounds.Porphines with halogen atoms in their molecules (compounds Ⅱ1_3) could not be excited and were non-fluorescent.This suggests that there was possibly a quenching effect of ha'ogen atoms on porphine fluorescence.
