BLOCKING EFFECT OF SEA BUCKTHORN JUICE ON THE FORMATION OF N-NITROSODIMETHYLANIINE (NDMA) IN VIVO IN RAT
- VernacularTitle:沙棘汁对致癌物N-二甲基亚硝胺(NDMA)在大鼠体内合成及诱癌的阻断与防护作用
- Author:
Yong LI
;
Huang LIU
- Publication Type:Journal Article
- Keywords:
sea buckthorn N-nitroso compounds carcinoma
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The formation of carcinomas of liver, lung and kidney in rats by feeding aminopyrine (AP) plus sodium nitrite (Na NO2) in diet was investigated. 72 young Wister rats were divided into A,B,C,D group. Group A was set as control receiving basal diet and tap water. Another 3 groups were given basal diet containing AP plus Na NO2 (2g/kg each). However, group B was given tap water, group C ascorbic acid solution, group D sea buckthorn (Hippophae rhamnoides L.) juice for drinking. After 38 week's feeding, group B developed tumors in the livers (17/17), lungs (6/17) and kidneys (4/17) and the average life-span was 195 days, group D delayed the development of tumors and the average life-span was 270 days, significantly longer than that of group B (195 days, p
