A STUDY ON FREQUENCY OF CHROMOSOME ABERRATION AND SISTER-CHROIATID EXCHANGE SN WORKERS EXPOSED TO DICHLORVOS
- VernacularTitle:敌敌畏生产工人染色体畸变和姐妹染色单体互换的研究
- Author:
Zhichao SHEN
- Publication Type:Journal Article
- Keywords:
dichlorvos;
chromosome aberration;
sister-chromatid exchange;
mutation
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The frequencies of chromosome aberrations (CA) and sister-chromatid exchanges (SCE) were investigated in the peripheral blood lymphocytes of 19 workers exposeu to dichlorvos and 10 non-exposed controls.The results showed that the frequency of SCE was significantly higher in the exposed group than that in the control group.However there was not statistical difference of the frequency of CA between the two groups.An increase of the frequency of SCE in the exposed group indicated the possibility of potential mutagenicity of dichlorvos.The results also showed that the frequency of SCE increased with duration of dichlorvos exposure, but it was not related to the effect of dichlorvos on ChE.The SCE changes recovered slowly after cessation of exposure to dichlorvos for an average period of 8.6 months.
