Effects of Exogenous No-DL-3-Hydroxybutyrate and Insulin on Skeletal Muscle Protein Metabolism in Rats after Early Severe Burn Injury
- VernacularTitle:严重烫伤早期外源性?-羟丁酸钠、胰岛素对大鼠骨骼肌蛋白质代谢的影响
- Author:
Qing YANG
;
Yanlin DONG
- Publication Type:Journal Article
- Keywords:
Sodium hydroxybutyrate;
Ketonc bodies;
Burn;
inury;
Protein metabolism;
3-methylhistidine
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of exogenous Na-DL-3-hydroxybutyate (3-HOBNa)and insulin(I) on skeletal muscle protein metabolism in rats inflicctcd with 37% TBSA full thickness scalding were studied It was found that the scrum acctoacctatc (AcAc) of the burned animals showed no significant difference from the control on the 4th day postburn,but the free fatty acid (FFA) decreased markedly and the urinary 3 - methylhistididne(3-MH) excretion and the protein de -gradation rate of the soleus muscle of the injured hind limb increased na kedly.Infusion of 3-HOBNa for 3 consecutive days following burns could lower the urinary 3-MH excretion and the protein,degradation rate of the soleus muscle with no significant influence on the skeletal muscle protein anabolism.Moreover,investigations revealed that there was no syncrgistic effect of insulin-kctone body combinalioan on the anti-catabolic capacity in burned rats.
