GASTRIC MUCOSAL BLOOD FLOW AND ACID SECRETION IN RATS
- VernacularTitle:大鼠胃粘膜血流量与泌酸关系
- Author:
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
gastric mucosal blood flow;
gastric acid;
H_2 antagonist. laser Doppler flowmetry
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between gastric mucosal blood flow (GMBF) and acid secretion was studied in rats by using secretory stimulant (pantagastrin) and inhibitor (cimetidine) GMBF was measured by laser Doppler flowmetry (LDF) and gastric mucosal pH determined by microglass pH electrode. GMBF was increased and gastric mucosal pH decreased significantly after intravenous injection of 6?g/kg of pcntagaslrin, while GMBF was decreased and gaslric mucosal pH increased markedly after intravenous administration of 109 mg/kg caretidine. This indicates that pentagastrin can increase GMBF and acid secretion, and cimctidine can decrease GMBF ang acid secretion.GBMF is closely relatel to acid secretion in rats
