Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats
- VernacularTitle:人参皂甙和酮布芬对烟雾吸入性肺损伤的影响
- Author:
Yuehua HUANG
- Publication Type:Journal Article
- Keywords:
Ginsenosides;
Ketoprofen;
Smoke inhalation injury;
Pulmonary vascular permeability;
Platelets aggregation
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In the control rabbits 6 h after smoke inhalation injury, the pulmonary vascular permeability and the circulating platelet aggregation percentage increased distinctly, pathological changes of trachea and lung were marked. In the other 2 groups, ginsenosides (25 mg/kg, iv) or ketoprofen (12 mg/kg, iv) were given 15 min after injury, 6 h after treatment, although both drugs decreased, the aggregation percentage of circulating platelets, only ginsenosides did alleviate the augmented pulmonary vascular permeabil ity and the pathological changes of trachea and lung. In the similar model of smoke inhalation injury in rats, ginsensi-des increased the PGI2 level in arterial blood and reduced the ratio of TXA2/ PGI2 1 h after treatment.
