EFFECTS OF PGE_2 & NIFEDIPINE ON SOME IMMUNOLOGIC FUNCTIONS
- VernacularTitle:前列腺素E_2及硝苯吡啶对某些免疫功能的影响
- Author:
Luoxiu ZHANG
;
Weimin XU
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
prostaglandin E_2;
Nefidipine;
Lymphocyte proliferation;
MIF;
Phagocytosis
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study,we observed that PGE2 3?10-7~3?10-6 mol/L & nifedipine 1 ?10-5mol/L inhibited lymphocyte proliferation markedly.The effect of nifedipine was completely reversible, however the effects of PGE2(3 ?10-6mol/L)was only partly reversible .In combination of PGE2(3?10-8mol/L) with nifedipine (1 ?10-6mol/L) ,the effect was additive,no significant antagonism and synergism were observed .PGE26? 10-6mol/L and nifedipine 1?10-3 mol/L directly inhibited maerbphage migration but no significant effect on PHA-induced MIF .Preincuba-tation with nefidipine did not influonce macrophage phagocytosis, but PGE2 slightly enhanced it. The results stated above strongly suggests that PGE2 may regulate cells interaction and Ca2+ is required during lymphocyte proliferation.
