THE PROTECTIVE EFFECT OF TGPs ON ACUTE LIVER INJURY INDUCED BY CARBON TETRACHLORIDE IN MICE
- VernacularTitle:白芍总甙对小鼠四氯化碳肝损伤模型的保护作用
- Author:
Yongxiang WANG
;
Weiqun WANG
;
Jiping HUANG
- Publication Type:Journal Article
- Keywords:
TGPs;
CC1_4;
GPT;
GOT;
LDH;
Histopathologic change
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The protective effect of TGPs on acute liver damage induced by carbon tetrachloride ( CCl4 ) was investigated in mice . TGPs ( 40 or 80mg/kg?d ? 3d, ip ) reduced the elevation of plasma or serume gl- utamic pyruvic transaminase ( GPT ) and plasma lactate dehydroge-nase ( LDH ) in CCl4-intoxicated mice, but if had no significant influence on the elevation of plasma glutamic oxalacetic transaminase ( GOT).TGPs (40mg/kg?d ? 3d, ip ) showed a protective effect on the histopathologic changes of liver injury induced by CCl4. The results suggest that TGPs may a protect against hepatic damage.
