Effects of Liposome-encapsulated Nitrogen Mustard on Acute Experimental Serum Sickness in Rabbits
- VernacularTitle:脂质体包裹的氮芥对家兔急性实验性血清病的影响
- Author:
Fan ZHOU
;
Xihua ZHU
- Publication Type:Journal Article
- Keywords:
Nitrogen mustard, Liposomes;
Macrophages;
Immune complex disease;
Serum sickness
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Nitrogen mustard encapsulated with liposomes was administered to the rabbits with acute experimental serum sickness(AESS). Then the serum levels of anti-BSA antibodies and circulating; immune complex(CIC), CH50, and WBC count were determined. The ACPase activity of spleen macrophages was measured. And the sections of renal tissues, after HE-stained, were studied for the accumulation of CIC and the pathological changes. It was found that liposome-encapsulated nitrogen mustard can increase the macrophage activity and in turn aggravate the renal damages of AESS rabbits.The results suggest that the renal damages of AESS rabbits can immunopatholo-gically be attributed to the increased activity of macrophages.
