The Role of Lipid Peroxidation in Lung Damage after Smoke Inhalation
- VernacularTitle:脂质过氧化在烟雾吸入性肺损伤机制中的作用
- Author:
Zhuodao ZHAO
- Publication Type:Journal Article
- Keywords:
Lipid peroxides;
Lung damage, inhalation;
Superoxide dismutase;
Oxygen free radicals;
Dogs
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The role of lipid peroxidation in the precipitation of umg damage after smoke inhalation was investigated in 16 dogs. Superoxide dismutase(SOD) activity and plasma MDA in arterial blood, and ethane in the exhaled air were determined to demonstrate oxygen free radicals and lipid peroxidation. PaO2 and extravascular lung water (EVLW) were determined to evaluate lung damage.It was found that in the early postinjury period, the experimental animals suffered from pulmonary edema and acute pulmonary dysfunction. MDA in arterial plasma and exhaled ethane markedly increased (P
