Pathological Changes of the Lungs after High-velocity Steel Bullet-induced-Bone Fracture in Pigs
- VernacularTitle:高速钢珠弹致股骨骨折及软组织创伤后肺病理形态变化的动物实验
- Author:
Guojian LIU
;
At ET
- Publication Type:Journal Article
- Keywords:
Lung;
Femur;
Wounds and injuries;
Respiratory distress syndrome, adult
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The histopathological and ultrastructural changes of the lungs of 11 pigs suffering from comminuted fracture of the femur produced by high-velocity sieel bullet were studied. The steel bullet was 7.62 mm in diameter and 1.03 g in weight. The pulmonary changes were observed 24, 48, and 72 hours after injury.It was found that microvascular congestion, aggregation of RBC and WBC, and degranulation of WBC were prominent features 24 hours after injury. The basement membrane of the endothelium was broken. Type I pneumocytes became swollen and deteriorated. The lamellar bodies of Type II pneumocytes were evacuated rapidly. 48 to 72 hours after injury, these pathological changes gradually ameliorated.The pulmonary pathology occurring after bullet - induced fracture observed in this study is similar to that of adult respiratory distress syndrome(ARDS) in character but much milder in intensity. Its prognosis is always fine. Most of the experimental animals showed no symptoms or signs of ARDS. It is concluded that severe limb trauma can induce subclinical ARDS.
