Relationship between Lipid Peroxidation and Cell Damage after High-velocity Missile Trauma with or without Hemorrhagic Shock
- VernacularTitle:高速投射物伤合并休克脂质过氧化反应与细胞损伤的关系
- Author:
Haichen SUN
- Publication Type:Journal Article
- Keywords:
Muscles;
Wounds and iujuries;
Shock, hemorrhagic;
Lipid peroxides;
Superoxide dismutase
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between lipid peroxidation and cell damage was studied in 8 dogs after they were inflicted with high-velocity missile trauma to the soft tissues of a leg and in another 8 to whom hemorrhagic shock was induced immediately after missile trauma. It was found that after trauma, the lipid peroxide(LPO) content of the muscle homogenate and mitochondria suspension of the wounded region and in plasma was markedly increased, and it had no tendency to restore to the normal until 12 hours after trauma. The increase of LPO occurred earlier in mitochondria suspension than in muscle homogenate. In addition, the activities of plasma creatine phosphokinase, acid phosphatase and cathepsin-D and of superoxide dismutase(SOD) were also increased, which was in significant correlation with LPO increase. The LPO content of the tissues of the remote regions remained un- changed. In the shock group, the LPO content of both the wounded region and the opposite leg was increased, which was in significant correlation with the increase of plasma enzyme activities, but SOD activity was markedly decreased,The results suggest that lipid peroxidation plays an important role in cell damage after high-velocity missile trauma and hemorrhagic shock. SOD may be activated as a compensatory response, but it is usually inhibited in severe trauma to result in irreversible damages.
