Combined Effects of Hypoxia and Pulmonary Microembolism on Pulmonary Extravascular Water in Rats
- VernacularTitle:缺氧复合肺微栓塞对大鼠肺含水量的影响
- Author:
Jie LIU
- Publication Type:Journal Article
- Keywords:
Anoxia;
Pulmonary embolism;
Lungs
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
Sixty-eight rats were randomly divided into 4 groups, the control group, hy-poxia group, pulmonary embolism group, and combied hypoxia-pulmonary embolism group. Hypoxia was created by putting the animals under a simulated 6000 meter altitude in hypobaric chamber for 48 hours, and pulmonary embolism in rats was induced by injecting toad red cells via the tail vein. The rats were anesthetized and right ventricular pressure.(RVP) was measured. Then 51Cr-labelled rat red cells were injected via the femoral vein. 10 minutes after injection, 1 ml of blood was drawn from the carotid artery and the lungs were excised. Eventually the dry weight of bloodless pulmonary tissues(PTDW), the lung-body index(ILB), and the pulmonary extravascular water(PEW) were obtained after calcutions according to the Balie's formula.It was found that either hypoxia or pulmonary embolism could increase RVP but the combination of hypoxia and embolism resulted in a more marked RVP increase, that the combined effect of hypoxia and pulmonary embolism could increase more markedly both PTDW and ILB than hypoxia alone, and that PEW showed a most significant increase in the combined hypoxia-pulmonary embolism group. These results indicate that the combined effect of hypoxia and pulmonary embolism can markedly increase PEW and the increase of PEW is related to high pulmonary vascular resistance, , which is the result of the damage of pulmonary microvasculalure by hypoxia and pulmonary microembolism.
